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- Title
A dynamic atlas of immunocyte migration from the gut.
- Authors
Galván-Peña, Silvia; Zhu, Yangyang; Hanna, Bola S.; Mathis, Diane; Benoist, Christophe
- Abstract
Dysbiosis in the gut microbiota affects several systemic diseases, possibly by driving the migration of perturbed intestinal immunocytes to extraintestinal tissues. Combining Kaede photoconvertible mice and single-cell genomics, we generated a detailed map of migratory trajectories from the colon, at baseline, and in several models of intestinal and extraintestinal inflammation. All lineages emigrated from the colon in an S1P-dependent manner. B lymphocytes represented the largest contingent, with the unexpected circulation of nonexperienced follicular B cells, which carried a gut-imprinted transcriptomic signature. T cell emigration included distinct groups of RORγ+ and IEL-like CD160+ subsets. Gut inflammation curtailed emigration, except for dendritic cells disseminating to lymph nodes. Colon-emigrating cells distributed differentially to distinct sites of extraintestinal models of inflammation (psoriasis-like skin, arthritic synovium, and tumors). Thus, specific cellular trails originating in the gut and influenced by microbiota may shape peripheral immunity in varied ways. Editor's summary: There is growing evidence that the interplay among enteric microbiota, dietary antigens, and immune cells located in the gut has systemic impacts in both health and disease. To better understand how the gut mediates interorgan communication, a clearer delineation of gut immune cell migration to the periphery is needed. Galván-Peña et al. used Kaede photoconvertible mice and single-cell RNA sequencing (scRNA-seq) to map the migration of immune cells from the colon at homeostasis, after gut injury, and in the context of extraintestinal inflammation. This approach revealed much greater dynamic immunocyte turnover than previously thought and uncovered unique patterns of migration that depended on the nature and location of inflammatory lesion. These findings may help to explain how perturbations in the gut microbiota can engender such distant and potent effects. —Seth Thomas Scanlon
- Subjects
B cells; INTESTINAL tumors; GUT microbiome; CELL migration; DENDRITIC cells; T cells
- Publication
Science Immunology, 2024, Vol 9, Issue 91, p1
- ISSN
2470-9468
- Publication type
Article
- DOI
10.1126/sciimmunol.adi0672