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- Title
Žloutenka kojeného dítěte.
- Authors
El-Lababidi, Nabil
- Abstract
Breast milk jaundice is a relatively common, benign condition, which is present in 20–30% of exclusively or predominantly breastfed infants. This type of jaundice usually manifests between the first and second week of life of the newborn and remains until the 8th–12th week of age. Its aetiology is not yet fully understood. The presence of factors affecting bilirubin metabolism in the breast milk is considered. Up to 70% of infants have a genetic mutation in UGT1A1*6. It seems that alterations of gut microbiota composition and its metabolites may affect the enterohepatic bilirubin circulation. The diagnosis of breast milk jaundice is based on exclusion of other causes of unconjugated hyperbilirubinemia. Should the total bilirubin level not fulfil phototherapy criteria, then no other intervention is required. However, clinical observation is recommended.
- Subjects
BREAST milk; ENTEROHEPATIC circulation; GENETIC mutation; GUT microbiome; BILIRUBIN; COMPOSITION of breast milk; JAUNDICE
- Publication
Pediatrie pro Praxi, 2023, Vol 24, Issue 5, p313
- ISSN
1213-0494
- Publication type
Article
- DOI
10.36290/ped.2023.079