We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The impact of depression and somatic symptoms on treatment outcomes in patients with chronic prostatitis/chronic pelvic pain syndrome: a preliminary study in a naturalistic treatment setting.
- Authors
Koh, J. S.; Ko, H. J.; Wang, S.‐M.; Cho, K. J.; Kim, J. C.; Lee, S.‐J.; Pae, C.‐U.
- Abstract
Aim The aim of this study was to evaluate the impact of depression and somatic symptoms on treatment outcomes in Korean male patients with chronic prostatitis/chronic pelvic pain syndrome ( CP/ CPPS) attending a routine clinical practice. Methods This was a 12-week prospective observational study ( n = 80). The Korean version of the National Institutes of Health Chronic Prostatitis Symptom Index ( NIH- CPSI) to measure the severity of CP/ CPPS, the Korean version of the Patient Health Questionnaire-9 ( PHQ-9) to assess depression, the Korean version of the Patient Health Questionnaire-15 ( PHQ-15) to evaluate somatisation and the Korean version of the EuroQol Questionnaire-5 Dimensions ( EQ-5D), specifically the EQ-5D utility index and the EQ-5D visual analogue scale ( EQ-5D VAS), to assess quality of life, were utilised and given at baseline and week 12. The primary and secondary end-points in this study were changes in the NIH- CPSI total score from baseline to week 12 according to depression and somatisation. Results The change in NIH- CPSI total score was significantly higher in those without depression than in those with depression (p = 0.003), with a magnitude of difference of 2.8. The responder rate (a ≥ 4 point decrease in NIH- CPSI total score from baseline) was significantly higher in those without depression (42.9%) than in those with depression (17.2%, p = 0.023). However, significant differences were not observed between the two groups in the other outcome measures or in all study outcomes between subjects with or without somatisation. A logistic regression analysis revealed that the presence or absence of depression may be a principal predictor of response to treatment. Conclusion These preliminary results indicate that depression may have a negative impact on treatment outcome and is a likely predictor of response to treatment in patients with CP/ CPPS. However, additional studies with adequate power and improved design are necessary to further support the present findings.
- Publication
International Journal of Clinical Practice, 2014, Vol 68, Issue 4, p478
- ISSN
1368-5031
- Publication type
Article
- DOI
10.1111/ijcp.12340