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- Title
Does concomitant diabetes affect treatment responses in overactive bladder patients?
- Authors
Schneider, T.; Marschall‐Kehrel, D.; Hanisch, J.‐U.; Michel, M. C.
- Abstract
Aims To compare the efficacy and tolerability of a muscarinic receptor antagonist, darifenacin, in the treatment of overactive bladder ( OAB) patients with concomitant diabetes as compared with those without comorbidities. Methods Post hoc exploratory analysis of a published, large, non-interventional study in OAB patients treated with darifenacin including 532 diabetics and 1315 controls. Associations of diabetes with treatment responses were evaluated by multiple regression models. Results Diabetics (largely type 2 patients) and controls differed in baseline age, body weight, duration of OAB symptoms and presence of comedications. However, they exhibited similar OAB symptom episode frequency and problem rating and received similar starting doses of darifenacin. Presence of diabetes was associated with a significantly smaller reduction of OAB symptoms, but the effect attributable to diabetes was small relative to the overall treatment response. The presence of diabetes was not associated with differences in tolerability. Discussion and conclusions We conclude that a muscarinic receptor antagonist has comparable efficacy and tolerability in the treatment of OAB patients with and without concomitant diabetes.
- Publication
International Journal of Clinical Practice, 2013, Vol 67, Issue 11, p1138
- ISSN
1368-5031
- Publication type
Article
- DOI
10.1111/ijcp.12196