We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Predictors of clinical progression in HIV-1-infected adults initiating combination antiretroviral therapy with advanced disease in the Asia-Pacific region: results from the TREAT Asia HIV observational database.
- Authors
Byakwaga, H; Petoumenos, K; Ananworanich, J; Zhang, F; Boyd, M A; Sirisanthana, T; Li, P C K; Lee, C; Mean, C V; Saphonn, V; Omar, S F S; Pujari, S; Phanuphak, P; Lim, P L; Kumarasamy, N; Chen, Y M A; Merati, T P; Sungkanuparph, S; Ditangco, R; Oka, S
- Abstract
The majority of HIV-infected patients in developing countries commences combination antiretroviral therapy (cART) with advanced disease. We examined predictors of disease progression in patients initiating cART with CD4 count ≤200 cells/mm(3) in the TREAT Asia HIV Observational Database. The main outcome measure was progression to either an AIDS-defining illness or death occurring 6 months after initiation of cART. We used survival analysis methods. A total of 1255 patients contributed 2696 person years of follow-up; 73 were diagnosed with AIDS and 9 died. The rate of progression to the combined end point was 3.0 per 100 person years. The factors significantly associated with a higher risk of disease progression were Indian ethnicity, infection through intravenous drug use, lower CD4 count, and hemoglobin ≤130 g/dL at 6 months. In conclusion, measurements of CD4 count and hemoglobin at month 6 may be useful for early identification of disease progression in resource-limited settings.
- Publication
Journal of the International Association of Providers of AIDS Care, 2013, Vol 12, Issue 4, p270
- ISSN
2325-9582
- Publication type
journal article
- DOI
10.1177/1545109712469684