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- Title
Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus.
- Authors
Barreto, Humberto Medeiros; Fontinele, Filipe Cerqueira; de Oliveira, Aldeídia Pereira; Rufino Arcanjo, Daniel Dias; dos Santos, Bernadete Helena Cavalcanti; de Abreu, Aislan Pereira Lira; Melo Coutinho, Henrique Douglas; da Silva, Romezio Alves Carvalho; de Sousa, Taciana Oliveira; Freire de Medeiros, Maria das Graças; das Graças Lopes Citó, Antonia Maria; Dantas Lopes, José Arimateia
- Abstract
The Lippia origanoides H.B.K. ethanol extract (LOEE) and hexane (LOHEX), dichloromethane (LODCM), and ethyl acetate (LOEA) fractions were tested for their antimicrobial activity alone or in combination with antibiotics against amethicillin resistant Staphylococcus aureus (MRSA) strain. The natural products did not show antimicrobial activity against multidrug resistant strain at the clinically significant concentrations tested. However, a modulatory effect in the antibacterial activity of the neomycin and amikacin was verified when LOEE, LOHEX and LODCM were added to the growth medium at subinhibitory concentrations. A similar modulation was found when the natural products were changed for chlorpromazine, an inhibitor of bacterial efflux pumps, suggesting the involvement of resistancemediated by efflux system in the MRSA tested. The fractions LOHEX and LODCMshowed a modulatory activity bigger than their majority compounds (carvacrol, thymol, and naringenin), indicating that this activity is not due to their majority compounds only, but it is probably due to a synergism between their chemical components. These results indicate that L. origanoides H.B.K. can be a source of phytochemicals able tomodify the phenotype of resistance to aminoglycosides in MRSA.
- Publication
BioMed Research International, 2014, Vol 2014, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2014/305610