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- Title
Neuroprotective function of 14-3-3 proteins in neurodegeneration.
- Authors
Shimada, Tadayuki; Fournier, Alyson E; Yamagata, Kanato
- Abstract
14-3-3 proteins are abundantly expressed adaptor proteins that interact with a vast number of binding partners to regulate their cellular localization and function. They regulate substrate function in a number of ways including protection from dephosphorylation, regulation of enzyme activity, formation of ternary complexes and sequestration. The diversity of 14-3-3 interacting partners thus enables 14-3-3 proteins to impact a wide variety of cellular and physiological processes. 14-3-3 proteins are broadly expressed in the brain, and clinical and experimental studies have implicated 14-3-3 proteins in neurodegenerative disease. A recurring theme is that 14-3-3 proteins play important roles in pathogenesis through regulating the subcellular localization of target proteins. Here, we review the evidence that 14-3-3 proteins regulate aspects of neurodegenerative disease with a focus on their protective roles against neurodegeneration.
- Subjects
BRAIN metabolism; CARRIER proteins; METABOLISM; NEURODEGENERATION; NEUROPROTECTIVE agents
- Publication
BioMed Research International, 2013, Vol 2013, p564534
- ISSN
2314-6133
- Publication type
Journal Article
- DOI
2013/564534