We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Glaucumolides A and B, Biscembranoids with New Structural Type from a Cultured Soft Coral Sarcophyton glaucum.
- Authors
Huang, Chiung-Yao; Sung, Ping-Jyun; Uvarani, Chokkalingam; Su, Jui-Hsin; Lu, Mei-Chin; Hwang, Tsong-Long; Dai, Chang-Feng; Wu, Shwu-Li; Sheu, Jyh-Horng
- Abstract
Glaucumolides A (1) and B (2), novel biscembranes composed of an unprecedented α,β-unsaturated ε-lactone, along with the known metabolites ximaolide A (3) and isosarcophytonolide D (4), were isolated from the cultured soft coral Sarcophyton glaucum. The structures of the new metabolites were determined by extensive spectroscopic analyses. Compounds 1 and 2 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. In anti-inflammation assay, compounds 1 and 2 displayed strong inhibition of superoxide anion generation and elastase release in human neutrophils stimulated by fMLP/CB. Furthermore, both 1 and 2 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein, and compounds 1−3 were found to effectively reduce the expression of cyclooxygenase-2 protein, in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
- Subjects
ALCYONACEA; METABOLITES; NITRIC-oxide synthases; CYCLOOXYGENASE 2; MACROPHAGES; CELL lines
- Publication
Scientific Reports, 2015, p15624
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep15624