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- Title
The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases.
- Authors
Lee, Jae-Won; Chun, Wanjoo; Lee, Hee Jae; Min, Jae-Hong; Kim, Seong-Man; Seo, Ji-Yun; Ahn, Kyung-Seop; Oh, Sei-Ryang; Thurnher, Martin
- Abstract
Macrophages play an important role in the innate and adaptive immune responses of organ systems, including the lungs, to particles and pathogens. Cumulative results show that macrophages contribute to the development and progression of acute or chronic inflammatory responses through the secretion of inflammatory cytokines/chemokines and the activation of transcription factors in the pathogenesis of inflammatory lung diseases, such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ARDS related to COVID-19 (coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)), allergic asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). This review summarizes the functions of macrophages and their associated underlying mechanisms in the development of ALI, ARDS, COVID-19-related ARDS, allergic asthma, COPD, and IPF and briefly introduces the acute and chronic experimental animal models. Thus, this review suggests an effective therapeutic approach that focuses on the regulation of macrophage function in the context of inflammatory lung diseases.
- Subjects
LUNG diseases; OBSTRUCTIVE lung diseases; COVID-19; ADULT respiratory distress syndrome; MACROPHAGES
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 4, p897
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10040897