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- Title
Regulation of Fibrotic Processes in the Liver by ADAM Proteases.
- Authors
Schmidt-Arras, Dirk; Rose-John, Stefan
- Abstract
Fibrosis in the liver is mainly associated with the activation of hepatic stellate cells (HSCs). Both activation and clearance of HSCs can be mediated by ligand–receptor interactions. Members of the a disintegrin and metalloprotease (ADAM) family are involved in the proteolytic release of membrane-bound ligands and receptor ectodomains and the remodelling of the extracellular matrix. ADAM proteases are therefore major regulators of intercellular signalling pathways. In the present review we discuss how ADAM proteases modulate pro- and anti-fibrotic processes and how ADAM proteases might be harnessed therapeutically in the future.
- Subjects
PROTEOLYTIC enzymes; LIVER cells; LIVER; EXTRACELLULAR matrix
- Publication
Cells (2073-4409), 2019, Vol 8, Issue 10, p1226
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells8101226