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- Title
Mitochondrial Homeostasis and Cellular Senescence.
- Authors
Vasileiou, Panagiotis V.S.; Evangelou, Konstantinos; Vlasis, Konstantinos; Fildisis, Georgios; Panayiotidis, Mihalis I.; Chronopoulos, Efstathios; Passias, Panagiotis-Georgios; Kouloukoussa, Mirsini; Gorgoulis, Vassilis G.; Havaki, Sophia
- Abstract
Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.
- Subjects
OLD age; HOMEOSTASIS
- Publication
Cells (2073-4409), 2019, Vol 8, Issue 7, p686
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells8070686