We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The role of serum methylglyoxal on diabetic peripheral and cardiovascular autonomic neuropathy: the ADDITION Denmark study.
- Authors
Hansen, C. S.; Jensen, T. M.; Jensen, J. S.; Nawroth, P.; Fleming, T.; Witte, D. R.; Lauritzen, T.; Sandbæk, A.; Charles, M.; Fleischer, J.; Vistisen, D.; Jørgensen, M. E.
- Abstract
Aims Cardiovascular autonomic neuropathy and diabetic peripheral neuropathy are common diabetic complications and independent predictors of cardiovascular disease. The glucose metabolite methylglyoxal has been suggested to play a causal role in the pathogeneses of diabetic peripheral neuropathy and possibly diabetic cardiovascular autonomic neuropathy. The aim of this study was to investigate the cross-sectional association between serum methylglyoxal and diabetic peripheral neuropathy and cardiovascular autonomic neuropathy in a subset of patients in the ADDITION-Denmark study with short-term screen-detected Type 2 diabetes (duration ~ 5.8 years). Methods The patients were well controlled with regard to HbA1c, lipids and blood pressure. Cardiovascular autonomic neuropathy was assessed by measures of resting heart rate variability and cardiovascular autonomic reflex tests. Diabetic peripheral neuropathy was assessed by vibration detection threshold ( n = 319), 10 g monofilament ( n = 543) and the Michigan Neuropathy Screening Instrument questionnaire ( n = 966). Painful diabetic neuropathy was assessed using the Brief Pain Inventory short form ( n = 882). Results No associations between methylglyoxal and cardiovascular autonomic reflex tests or any measures of diabetic peripheral neuropathy or painful diabetic neuropathy were observed. However, a positive association between methylglyoxal and several heart rate variability indices was observed, although these associations were not statistically significant when corrected for multiple testing. Conclusion Serum methylglyoxal is not associated with cardiovascular autonomic neuropathy, diabetic peripheral neuropathy or painful diabetic neuropathy in this cohort of well-treated patients with short-term diabetes.
- Subjects
DENMARK; AUTONOMIC nervous system physiology; DIAGNOSIS of diabetic neuropathies; HEART disease risk factors; HYPERTENSION; CARDIOVASCULAR disease diagnosis; SMOKING; TYPE 2 diabetes complications; LIPID analysis; ANTHROPOMETRY; ANTILIPEMIC agents; BLOOD pressure; BLOOD pressure measurement; CARDIOLOGY; CHOLESTEROL; CONFIDENCE intervals; PEOPLE with diabetes; GLYCOSYLATED hemoglobin; HEART rate monitoring; HIGH density lipoproteins; PATIENT aftercare; HYPOGLYCEMIC agents; ANTIHYPERTENSIVE agents; LOW density lipoproteins; TYPE 2 diabetes; ORGANIC compounds; QUESTIONNAIRES; TRIGLYCERIDES; URINALYSIS; WORLD Health Organization; DATA analysis; ALBUMINS; BODY mass index; RANDOMIZED controlled trials; DATA analysis software; WAIST circumference
- Publication
Diabetic Medicine, 2015, Vol 32, Issue 6, p778
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/dme.12753