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- Title
Aldehyde Dehydrogenase 2 Has Cardioprotective Effects on Myocardial Ischaemia/Reperfusion Injury via Suppressing Mitophagy.
- Authors
Junhui Xing; Wenqing Ji; Shujian Wei; Qiuhuan Yuan; Jiali Wang; Feng Xu; Yuguo Chen; Panpan Hao
- Abstract
Mitophagy, a selective form of autophagy, is excessively activated in myocardial ischemia/reperfusion (I/R). The study investigated whether aldehyde dehydrogenase 2 (ALDH2) exerted its cardioprotective effect by regulating mitophagy. Myocardial infarct size and apoptosis after I/R in rats were ameliorated by Alda-1, an ALDH2 activator, and aggravated by ALDH2 inhibition. Both in I/R rats and hypoxia/reoxygenation H9C2 cells, ALDH2 activation suppressed phosphatase and tensin homolog-induced putative kinase 1 (PINK1)/Parkin expression, regulating mitophagy, by preventing 4-hydroxynonenal, reactive oxygen species and mitochondrial superoxide accumulation. Furthermore, the effect was enhanced by ALDH2 inhibition. Thus, ALDH2 may protect hearts against I/R injury by suppressing PINK1/Parkin-dependent mitophagy.
- Subjects
ALDEHYDE dehydrogenase; MYOCARDIAL reperfusion complications; LABORATORY rats
- Publication
Frontiers in Pharmacology, 2016, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2016.00101