We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Amelioration of Lupus Serum-Induced Skin Inflammation in CD64-Deficient Mice.
- Authors
Jiang, Lijuan; Han, Xiaoxiao; Qiu, Wenlin; Yu, Tong; Feng, Ruizhi; Wang, Xuefei; Duan, Xiaoru; Deng, Guo-Min
- Abstract
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by high autoantibodies levels and multiorgan tissue damage. The current study investigated the role of CD64 in SLE patients and animal models. According to a flow cytometry study, SLE patients showed an increase in CD64 expression in circulating monocytes. There was a correlation between CD64 and SLEDAI, blood urea nitrogen levels, and anti-Sm antibodies. In skin lesions of lupus MRL/ lpr mice, there was high IgG deposition and CD64 expression. In vitro , cytokines IL-10 and IFN-γ upregulated CD64 expression in monocytes/macrophages that was inhibited by glucocorticoids. In CD64-deficient mice, skin inflammation induced by lupus serum was reduced. Furthermore, activation of spleen tyrosine kinase (Syk), Akt, and extracellular signal-regulated kinase (Erk) was inhibited in CD64-deficient monocytes. The results suggest that CD64 could be a biomarker for observing SLE progression, as well as a mechanistic checkpoint in lupus pathogenesis.
- Subjects
SKIN inflammation; SYSTEMIC lupus erythematosus; BLOOD urea nitrogen; PROTEIN-tyrosine kinases; AUTOIMMUNE diseases
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.824008