We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.
- Authors
Hirayama, S.; Terasawa, K.; Rabeler, R.; Hirayama, T.; Inoue, T.; Tatsumi, Y.; Purpura, M.; Jäger, R.
- Abstract
Background Attention-deficit hyperactivity disorder ( ADHD) is the most commonly diagnosed behavioural disorder of childhood, affecting 3-5% of school-age children. The present study investigated whether the supplementation of soy-derived phosphatidylserine ( PS), a naturally occurring phospholipid, improves ADHD symptoms in children. Methods Thirty six children, aged 4-14 years, who had not previously received any drug treatment related to ADHD, received placebo ( n = 17) or 200 mg day-1 PS ( n = 19) for 2 months in a randomised, double-blind manner. Main outcome measures included: (i) ADHD symptoms based on DSM- IV- TR; (ii) short-term auditory memory and working memory using the Digit Span Test of the Wechsler Intelligence Scale for Children; and (iii) mental performance to visual stimuli ( GO/ NO GO task). Results PS supplementation resulted in significant improvements in: (i) ADHD ( P < 0.01), AD ( P < 0.01) and HD ( P < 0.01); (ii) short-term auditory memory ( P < 0.05); and (iii) inattention (differentiation and reverse differentiation, P < 0.05) and inattention and impulsivity ( P < 0.05). No significant differences were observed in other measurements and in the placebo group. PS was well-tolerated and showed no adverse effects. Conclusions PS significantly improved ADHD symptoms and short-term auditory memory in children. PS supplementation might be a safe and natural nutritional strategy for improving mental performance in young children suffering from ADHD.
- Subjects
ATTENTION-deficit hyperactivity disorder; ANALYSIS of variance; ATTENTION; CHILDREN'S health; CHILD nutrition; DIETARY supplements; NEUROPSYCHOLOGICAL tests; MEMORY; CLASSIFICATION of mental disorders; PHOSPHOLIPIDS; RESEARCH funding; STATISTICAL sampling; SOYBEAN; T-test (Statistics); ADOLESCENT health; THOUGHT &; thinking; ADOLESCENT nutrition; PLANT extracts; STATISTICAL power analysis; STATISTICAL significance; EFFECT sizes (Statistics); RANDOMIZED controlled trials; BLIND experiment; DESCRIPTIVE statistics; CHILDREN; PREVENTION
- Publication
Journal of Human Nutrition & Dietetics, 2014, p284
- ISSN
0952-3871
- Publication type
Article
- DOI
10.1111/jhn.12090