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- Title
Effect of gastric distension with concurrent small intestinal saline or glucose infusion on incretin hormone secretion in healthy individuals: A randomized, controlled, crossover study.
- Authors
Jalleh, Ryan J.; Trahair, Laurence G.; Wu, Tongzhi; Standfield, Scott; Feinle‐Bisset, Christine; Rayner, Christopher K.; Horowitz, Michael; Jones, Karen L.
- Abstract
Aim: To evaluate the effect of gastric distension, induced using a gastric 'barostat', on the secretion of glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) in the presence and absence of small intestinal nutrients in healthy individuals. Materials and Methods: Eight healthy participants (two females, six males, mean age 69.3 ± 1.2 years, body mass index 23.5 ± 0.8 kg/m2) were each studied on four occasions when they received an intraduodenal infusion of either (i) 0.9% saline or (ii) glucose delivered at a rate of 3 kcal/min both with, and without, an intragastric balloon with the pressure set to 8 mmHg above the intragastric minimum distending pressure. Results: Following intraduodenal saline or glucose infusion, there was no difference in plasma GLP‐1 with or without gastric distension (P = 1.00 for both saline and glucose infusions). There was also no difference in plasma GIP with or without gastric distension (P = 1.00 for saline infusion and P =.99 for glucose infusion). Conclusions: Gastric distension, either alone or during small intestinal glucose exposure, does not stimulate incretin hormone secretion significantly in healthy humans.
- Subjects
GLUCOSE; SECRETION; GASTRIC emptying; BODY mass index; INTESTINES
- Publication
Diabetes, Obesity & Metabolism, 2023, Vol 25, Issue 7, p1849
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.15042