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- Title
β-Cell mass plasticity in type 2 diabetes.
- Authors
del Prato, S.; Wishner, W. J.; Gromada, J.; Schluchter, B. J.
- Abstract
Prospective studies have shown that insulin resistance (IR) and impaired insulin secretion are independent predecessors and predictors of overt diabetes in genetically predisposed individuals. With the onset of IR, rates of both insulin biosynthesis and secretion are amplified, coupled with increases in β3-cell mass and hypertrophy of existing β-cells to meet the increase in demand. After years of controversy regarding the primacy of either a &beta-cell defect or IR in the pathogenesis of T2D, this article now recognizes that various degrees of both alterations must coexist for hyperglycaemia to become manifest.
- Subjects
BIOSYNTHESIS; ENDOCRINE diseases; INSULIN; DIABETES complications; HYPOGLYCEMIC agents; DRUG resistance; INSULIN resistance; LIVER cells; HYPERTROPHY
- Publication
Diabetes, Obesity & Metabolism, 2004, Vol 6, Issue 5, p319
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/j.1462-8902.2004.00360.x