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- Title
Folic Acid Functionalized Nanoprobes for Fluorescence-, Dark-Field-, and Dual-Imaging-Based Selective Detection of Cancer Cells and Tissue.
- Authors
Maity, Amit Ranjan; Saha, Arindam; Roy, Arun; Jana, Nikhil R.
- Abstract
Folate-functionalized quantum dots, gold/silver nanoparticles, and magnetic quantum dots have been synthesized and used as fluorescence, dark-field, and dual-imaging probes for the detection of cancer cells and tissues. A very efficient and generalized folate-functionalization method has been developed for various amine-terminated nanoparticles. The advantages of the presented approach are that it can be used to synthesize a wide range of folate-functionalized nanoparticles and the number of folate molecules per nanoparticle can be controlled easily to tune their interaction with folate receptors present at the cell surface. These folate-functionalized nanoparticles have been used as cellular and tissue-imaging bioprobes. Results show that folate-functionalized nanoparticles act as efficient and selective imaging probes in targeting cancer cells and tissues and labeled cells/tissues can be detected by using different imaging modalities.
- Subjects
FOLIC acid deficiency; TISSUES; CANCER cells; QUANTUM dots; QUANTUM electronics
- Publication
ChemPlusChem, 2013, Vol 78, Issue 3, p259
- ISSN
2192-6506
- Publication type
Article
- DOI
10.1002/cplu.201200296