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- Title
Insights from the Breast Cancer Screening Trials: How Screening Affects the Natural History of Breast Cancer and Implications for Evaluating Service Screening Programs.
- Authors
Tabár, László; Yen, Amy Ming‐Fang; Wu, Wendy Yi‐Ying; Chen, Sam Li‐Sheng; Chiu, Sherry Yueh‐Hsia; Fann, Jean Ching‐Yuan; Ku, May Mei‐Sheng; Smith, Robert A; Duffy, Stephen W; Chen, Tony Hsiu‐Hsi
- Abstract
It is desirable to have a strategy for evaluation of breast cancer service screening programs years before the long-term breast cancer mortality data are available. Since successful mammography screening has a significant impact on two components of the TNM (tumor size, node status, presence or absence of distant metastases) classification system, tumor size and node status, we investigated the effect of the randomized breast screening trials on incidence of advanced stage disease and on the subsequent breast cancer death rate. In the trials that achieved a 20% or greater reduction in advanced stage disease, there was an average breast cancer mortality reduction of 28% among women invited to screening (attenders and nonattenders combined). In the trials that achieved a reduction in advanced stage disease of less than 10%, there was no reduction in breast cancer mortality among women invited to screening. This study provides evidence that the average mortality reduction in all the trials underestimates the true mortality reduction, and that substantially greater breast cancer mortality reductions can be expected in screening programs that are effective in reducing advanced stage breast cancer. In addition, monitoring the incidence of advanced stage breast cancer in an ongoing screening program can provide a sensitive and early indicator of the subsequent mortality from the disease.
- Subjects
BREAST tumor diagnosis; BREAST tumor treatment; BREAST tumors; CONFIDENCE intervals; META-analysis; RESEARCH funding; TUMOR classification; RELATIVE medical risk; DESCRIPTIVE statistics; EARLY detection of cancer; EVALUATION
- Publication
Breast Journal, 2015, Vol 21, Issue 1, p13
- ISSN
1075-122X
- Publication type
Article
- DOI
10.1111/tbj.12354