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- Title
LncTar: a tool for predicting the RNA targets of long noncoding RNAs.
- Authors
Jianwei Li; Wei Ma; Pan Zeng; Junyi Wang; Bin Geng; Jichun Yang; Qinghua Cui
- Abstract
Long noncoding RNAs (lncRNAs) represent a big category of noncoding RNA molecules, and increasing studies have shown that they play important roles in various critical biological processes. They show a diversity of functions through diverse mechanisms, among which regulating RNA molecules is one of the most popular ones. Given the big number of lncRNAs, it becomes urgent and important to predict the RNA targets of lncRNAs in a large scale for the comprehensive understanding of lncRNA functions and action mechanisms. Although several methods have been developed to predict RNA-RNA interactions, none of them can be used to predict the RNA targets of lncRNAs in a large scale. Here we presented a tool, LncTar, which shows the ability to efficiently predict the RNA targets of lncRNAs in a large scale. To test the accuracy of LncTar, we applied it to 10 experimentally supported lncRNA-mRNA interactions. As a result, LncTar successfully predicted 8 (80%) of the 10 lncRNA-mRNA pairs, suggesting that LncTar has a reliable accuracy. Finally, we believe that LncTar could be an efficient tool for the fast identification of the RNA targets of lncRNAs. LncTar is freely available at http://www.cuilab.cn/lnctar.
- Subjects
NON-coding RNA; RNA-RNA interactions; RNA sequencing; NUCLEOTIDE sequence; BIOINFORMATICS
- Publication
Briefings in Bioinformatics, 2015, Vol 16, Issue 5, p806
- ISSN
1467-5463
- Publication type
Article
- DOI
10.1093/bib/bbu048