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- Title
Two types of cone bipolar cells express voltage-gated Na+channels in the rat retina.
- Authors
JINJUAN CUI; ZHUO-HUA PAN
- Abstract
AbstractTwo groups of retinal cone bipolar cells (CBCs) in rats were found to express voltage-gated Na+channels. The axon terminals of the first group stratify in sublamina 2 of the inner plexiform layer (IPL) and partially overlap with the OFF-cholinergic band. This group was identified as type 3 CBCs. The axon terminals of the second group stratify in sublamina 3 of the IPL, slightly distal to the ON-cholinergic band. Cells of this second group resemble type 5 CBCs. In addition, we observed another group of ON-type CBCs with terminal stratification similar to that of the second group. However, this latter group did not show any Na+current, instead exhibiting a large hyperpolarization-activated cyclic nucleotide-gated cation current, suggesting the existence of two subclasses of physiologically distinct type 5 CBCs. Both groups of Na+-expressing bipolar cells were capable of generating a rapid tetrodotoxin-sensitive action potential as revealed by current injection. Multiple spike-like potentials were also observed in some of these cells. Results of this study provide valuable insights into the function of voltage-gated Na+channels of retinal bipolar cells in retinal processing.
- Subjects
ION channels; SODIUM ions; RETINA; AXONS; ACTION potentials; LABORATORY rats
- Publication
Visual Neuroscience, 2008, Vol 25, Issue 5/6, p635
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/S0952523808080851