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- Title
Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer.
- Authors
Luo, J.‐C.; Huang, K.‐W.; Leu, H.‐B.; Chen, L.‐C.; Hou, M.‐C.; Li, C.‐P.; Lu, C.‐L.; Lin, H.‐C.; Lee, F.‐Y.; Lee, S.‐D.
- Abstract
Aliment Pharmacol Ther 2011; 34: 519-525 Summary Background Clopidogrel does not inhibit prostaglandin synthesis. As a result, clopidogrel's incidence of peptic ulcer disease (PUD) and ulcer bleeding is lower than aspirin's. Aim To compare the healing rate in aspirin-related dyspeptic ulcer patients who were given proton pump inhibitor (PPI) plus aspirin or PPI plus clopidogrel. Methods Patients with aspirin-related nonbleeding symptomatic ulcers were randomised to receive rabeprazole (20 mg/day) plus aspirin (100 mg/day) or rabeprazole (20 mg/day) plus clopidogrel (75 mg/day) for 12 weeks. The primary endpoint was the successful treatment of PUD as characterised by intention-to-treat at the end of therapy. Results Two hundred and eighteen patients (109 in the aspirin group and 109 in the clopidogrel group) were enrolled. There were no statistical demographic differences between the group that received aspirin and the group that received clopidogrel. The PUD treatment success rate was also statistically equal between the clopidogrel and aspirin groups (86.2% vs. 90.0%, P = 0.531). Neither group experienced ulcer-related bleeding. Multivariate logistic regression analysis showed that large ulcer size (>10 mm) (OR: 6.29, 95% CI: 2.58-15.37) and past history of PUD (OR: 3.69, 95% CI: 1.24-10.97) were important predictors of unsuccessful therapy for aspirin-related PUD. Conclusions Rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel in treating aspirin-related symptomatic PUD. Large ulcer size (>10 mm) and past history of PUD are important predictors of unsuccessful therapy (NCT 01037491).
- Subjects
CLINICAL trials; ASPIRIN; PROTON pump inhibitors; PEPTIC ulcer; ULCER treatment; CLOPIDOGREL; PROSTAGLANDIN synthesis; MULTIVARIATE analysis
- Publication
Alimentary Pharmacology & Therapeutics, 2011, Vol 34, Issue 5, p519
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2011.04760.x