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- Title
Neurocognitive functions of pediatric kidney transplant recipients.
- Authors
Molnar-Varga, Marta; Novak, Marta; Szabo, Attila; Kelen, Kata; Streja, Elani; Remport, Adam; Mucsi, Istvan; Molnar, Miklos; Reusz, Gyorgy
- Abstract
Background: End-stage renal disease (ESRD) in children is associated with impaired neurocognitive function and development. However, data on factors associated with neurocognitive dysfunctions in children with kidney transplants are limited. Methods: We conducted a cross-sectional analysis comparing cognitive functions (using the Woodcock-Johnson International Edition, WJIE) in 35 kidney transplant and 35 healthy control children. Data on laboratory measurements, comorbidities, and social characteristics were collected. Results: Transplant children had significantly worse scores on the intelligence quotient (IQ) test compared with controls [Full Scale IQ score 85 (26) vs 107 (10), p <0.001]. Lower maternal education level was significantly associated with lower WJIE cognitive test scores; however, no association was found between laboratory values and WJIE scores. Among children with kidney transplants, those with medical comorbid conditions had significantly lower Verbal Ability and Full Scale IQ scores. Earlier age of dialysis onset and a longer total time on dialysis (>9 months) were associated with lower test scores. Age-standardized duration of hospitalization was inversely correlated with IQ ( r = −0.46, p <0.01) and was an independent significant predictor (Beta = −0.38, p = 0.02) of IQ scores in transplanted children. Conclusions: Child kidney transplant recipients have neurocognitive function impairments that are associated with markers of socioeconomic status (SES) and factors related to disease severity.
- Subjects
HUNGARY; CHRONIC kidney failure complications; ACADEMIC medical centers; CHILDREN'S health; COGNITION disorders; STATISTICAL correlation; HEMODIALYSIS; INTELLECT; INTELLIGENCE tests; KIDNEY transplantation; MULTIVARIATE analysis; REGRESSION analysis; RESEARCH funding; STATISTICS; T-test (Statistics); TRANSPLANTATION of organs, tissues, etc.; DATA analysis; SOCIOECONOMIC factors; CROSS-sectional method; TREATMENT duration; DESCRIPTIVE statistics; MANN Whitney U Test; ONE-way analysis of variance
- Publication
Pediatric Nephrology, 2016, Vol 31, Issue 9, p1531
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-016-3380-y