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- Title
Electrochemical detection of the neurotransmitter glutamate and the effect of the psychotropic drug riluzole on its oxidation response.
- Authors
Yu, Tao; Cui, Jingjie; Chen, Shaowei
- Abstract
Glutamate is the main excitatory neurotransmitter in the brain and plays a leading role in degenerative diseases, such as motor neuron diseases. Riluzole is a glutamate regulator and a therapeutic drug for motor neuron diseases. In this work, the interaction between glutamate and riluzole was studied using cyclic voltammetry and square-wave voltammetry at a glassy carbon electrode (GCE). It was shown that glutamate underwent a two-electron transfer reaction on the GCE surface, and the electrochemical detection limits of glutamate and riluzole were 483 μmol/L and 11.47 μmol/L, respectively. The results confirm that riluzole can promote the redox reaction of glutamate. This work highlights the significance of electrochemical technology in the sensing detection of the interaction between glutamate and related psychotropic drugs.
- Subjects
PSYCHOPHARMACOLOGY; RILUZOLE; MOTOR neuron diseases; GLUTAMIC acid; CARBON electrodes; CYCLIC voltammetry
- Publication
Analytical & Bioanalytical Chemistry, 2024, Vol 416, Issue 7, p1707
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-024-05175-2