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- Title
Mild gray matter atrophy in patients with long-standing multiple sclerosis and favorable clinical course.
- Authors
Cortese, Rosa; Battaglini, Marco; Parodi, Francesca; Stromillo, Maria Laura; Portaccio, Emilio; Razzolini, Lorenzo; Giorgio, Antonio; Sormani, Maria Pia; Amato, Maria Pia; De Stefano, Nicola
- Abstract
The mechanisms responsible for the favorable clinical course in multiple sclerosis (MS) remain unclear. In this longitudinal study, we assessed whether magnetic resonance imaging (MRI)-based changes in focal and diffuse brain damage are associated with a long-term favorable MS diseases course. We found that global brain and gray matter (GM) atrophy changes were milder in MS patients with long-standing disease (⩾30 years from onset) and favorable (no/minimal disability) clinical course than in sex-age-matched disable MS patients, independently of lesions accumulation. Data showed that different trajectories of volume changes, as reflected by mild GM atrophy, may characterize patients with long-term favorable evolution.
- Subjects
MULTIPLE sclerosis; GRAY matter (Nerve tissue); MAGNETIC resonance imaging; ATROPHY; LONG-Term Evolution (Telecommunications)
- Publication
Multiple Sclerosis Journal, 2022, Vol 28, Issue 1, p154
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585211019650