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- Title
Allelic variation in HLA-DRB1* loci in Syrian pemphigus vulgaris patients.
- Authors
Harfouch, Elham; Daoud, Saleh
- Abstract
Background Pemphigus vulgaris ( PV) is known to be strongly associated with particular alleles of the human leukocyte antigen ( HLA)- DRB1* loci. However, to date, the association of HLA with pemphigus has not been studied in a Syrian population. Objectives We aimed to study HLA- DRB1* loci variation in Syrian PV patients. Methods We used a sequence-specific primer polymerase chain reaction method to define the allele type of the DRB1* loci in 91 patients with PV and 270 healthy control subjects. Results We noticed an increased frequency of HLA- DRB1*04 and DRB1*14 alleles in patients with PV compared with healthy control subjects (67.0% vs. 26.3%; odds ratio [ OR] = 5.7, corrected P < 0.0001 for DRB1*04; 54.9% vs. 11.0%; OR = 9.5, corrected P < 0.0001 for DRB1*14). Among DRB1*04-positive PV patients, the DRB1*402 subtype was markedly increased compared with DRB1*04-positive healthy controls (84.3% vs. 26.7%; corrected P = 0.002), whereas the DRB1*0403 variant was represented more commonly in DRB1*04-positive healthy individuals than in DRB1*04-positive PV patients (45.0% vs. 1.6%; corrected P < 0.0001). In addition, the frequency of DRB1*11 was significantly decreased in PV patients compared with healthy controls (19.7% vs. 50.4%; OR = 0.25, corrected P < 0.0001). Conclusions The occurrence of PV is positively associated with HLA- DRB1*14 and HLA- DRB1*0402 but negatively associated with HLA- DRB1*11 in the Syrian population.
- Subjects
PEMPHIGUS; HLA histocompatibility antigens; ALLELES; GENETIC polymorphism research; SKIN disease genetics; GENETICS
- Publication
International Journal of Dermatology, 2014, Vol 53, Issue 12, p1460
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.12184