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- Title
Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance.
- Authors
Tae Jung Oh; Se Hee Min; Chang Ho Ahn; Eun Ky Kim; Soo Heon Kwak; Hye Seung Jung; Kyong Soo Park; Young Min Cho
- Abstract
Background: Subjects with normal glucose tolerance (NGT) who have a high 1-hour postload plasma glucose level (>155 mg/ dL; NGT 1 hour-high) have been shown to be at higher risk for type 2 diabetes than subjects with NGT 1 hour-low postload plasma glucose level (<155 mg/dL). We compared β-cell function in subjects with NGT 1 hour-high, NGT 1 hour-low, and impaired glucose tolerance (IGT). Methods: We classified subjects into NGT 1 hour-low (n= 149), NGT 1 hour-high (n=43), and IGT (n=52). The β-cell function was assessed based on insulinogenic index (IGI), oral disposition index (DI), and insulin secretion-sensitivity index-2 (ISSI-2). Results: Insulin sensitivity was comparable between the subjects with NGT 1 hour-high and NGT 1 hour-low. The β-cell function with/without adjusting insulin sensitivity was significantly different among the three groups. The IGI (pmol/mmol) was 116.8±107.3 vs. 64.8±47.8 vs. 65.8±80.6 (P=0.141), oral DI was 3.5±4.2 vs. 1.8±1.4 vs. 1.8±3.1 (P<0.001), and ISSI-2 was 301.2±113.7 vs. 213.2±67.3 vs. 172.5±87.5 (P<0.001) in NGT 1 hour-low, NGT 1 hour-high, and IGT, respectively. Post hoc analyses revealed that oral DI and ISSI-2 were significantly different between NGT 1 hour-low and NGT 1 hour-high but comparable between NGT 1 hour-high and IGT. Conclusion: Among Korean subjects with NGT, those who have a higher 1-hour postload glucose level have a compromised insulin- sensitivity adjusted β-cell function to a similar degree as IGT subjects.
- Subjects
GLUCOSE tolerance tests; BLOOD sugar; PANCREATIC beta cells; DIABETES; DISEASE prevalence
- Publication
Diabetes & Metabolism Journal, 2015, Vol 39, Issue 2, p147
- ISSN
2233-6079
- Publication type
Article
- DOI
10.4093/dmj.2015.39.2.147