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- Title
Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension.
- Authors
Ranasinghe, A. Dushani C. U.; Tennakoon, T. M. Parinda B.; Schwarz, Margaret A.
- Abstract
Pulmonary Hypertension (PH) is a terminal disease characterized by severe pulmonary vascular remodeling. Unfortunately, targeted therapy to prevent disease progression is limited. Here, the vascular cell populations that contribute to the molecular and morphological changes of PH in conjunction with current animal models for studying vascular remodeling in PH will be examined. The status quo of epigenetic targeting for treating vascular remodeling in different PH subtypes will be dissected, while parallel epigenetic threads between pulmonary hypertension and pathogenic cancer provide insight into future therapeutic PH opportunities.
- Subjects
VASCULAR remodeling; PULMONARY hypertension; EPIGENETICS; CELL populations; PULMONARY circulation
- Publication
Cells (2073-4409), 2024, Vol 13, Issue 3, p244
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells13030244