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- Title
Omega‐3 fatty acids and endothelial function: A GRADE‐assessed systematic review and meta‐analysis.
- Authors
Arabi, Seyyed Mostafa; Bahari, Hossein; Chambari, Mahla; Bahrami, Leila Sadat; Mohaildeen Gubari, Mohammaed Ibrahim; Watts, Gerald F.; Sahebkar, Amirhossein
- Abstract
Introduction: N‐3 polyunsaturated fatty acids (PUFAs) supplementation has been reported to have an impact on flow‐mediated dilatation (FMD), a conventionally used clinical technique for estimating endothelial dysfunction. However, its proven effects on endothelial function are unclear. This systematic review and meta‐analysis were conducted to evaluate the effects of n‐3 PUFAs supplementation on FMD of the brachial artery. Method: This study was performed following the PRISMA guidelines. To identify eligible RCTs, a systematic search was completed in PubMed/Medline, Scopus and Web of Science using relevant keywords. A fixed‐ or random‐effects model was utilized to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI). Results: Thirty‐two studies (with 35 arms) were included in this meta‐analysis, involving 2385 subjects with intervention duration ranging from 4 to 48 weeks. The pooled meta‐analysis demonstrated a significant effect of omega‐3 on FMD (WMD = 0.8%, 95% CI = 0.3–1.3, p =.001) and heterogeneity was significant (I2 = 82.5%, p <.001). Conclusion: We found that n‐3 PUFA supplementation improves endothelial function as estimated by flow‐mediated dilatation of the brachial artery.
- Subjects
OMEGA-3 fatty acids; UNSATURATED fatty acids; BRACHIAL artery; ESTIMATION theory; ENDOTHELIUM diseases
- Publication
European Journal of Clinical Investigation, 2024, Vol 54, Issue 2, p1
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.14109