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- Title
Fatal outcome of european tick-borne encephalitis after Vaccine Failure.
- Authors
Sendi, Parham; Hirzel, Cédric; Pfister, Stefan; Ackermann-Gäumann, Rahel; Grandgirard, Denis; Hewer, Ekkehard; Nirkko, Arto C.
- Abstract
Tick-borne encephalitis is a viral disease affecting the central nervous system. It is endemic in Switzerland with 200-250 notified cases annually. Active immunization is effective for persons in all age groups. Vaccine failure is rare, in particular after a completed vaccination course. Here, we describe the case of 67-year-old man with a fatal outcome despite vaccination. The diagnosis was confirmed by extensive postmortem analyses. The diagnostic challenges of vaccine failure in tick-borne encephalitis and the dynamics of the immune response in vaccination breakthrough are discussed.
- Subjects
DRUG side effects; DISEASES in men; TICK-borne encephalitis; IMMUNE response; DIAGNOSIS; VACCINATION
- Publication
Frontiers in Neurology, 2017, Vol 8, p1
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2017.00119