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- Title
Male Patients with Longstanding Type 2 Diabetes Have a Higher Incidence of Hypoglycemia Compared with Female Patients.
- Authors
Li, Feng-fei; Zhang, Ying; Zhang, Wen-li; Liu, Xiao-mei; Chen, Mao-yuan; Sun, Yi-xuan; Su, Xiao-fei; Wu, Jin-dan; Ma, Jian-hua; Ye, Lei
- Abstract
Introduction: To explore whether there was a gender difference in the risk of hypoglycemia during intensive insulin therapy in patients with longstanding type 2 diabetes (T2D). This was a post hoc analysis of a single-center, open-label and prospective trial.Methods: All subjects were admitted as inpatients, underwent a standard bread meal test at baseline and received a 7-day continuous subcutaneous insulin infusion (CSII) therapy for achieving glycemic control. Patients then were randomized 1:1 to two groups receiving (1) 4 days of Novo Mix 30 followed by 2 days of Humalog Mix 50; (2) 4 days of Humalog Mix 50 followed by 2 days of Novo Mix 30. All patients were subjected to 4-day retrospective continuous glucose monitoring (CGM) during the last 4 days in this study. The primary outcome was the incidences of hypoglycemia monitored by CGM at the end point.Results: A total of 102 patients met the inclusion criteria and completed the study. Our data revealed that 29 patients (28%) experienced hypoglycemia as detected by CGM at the end point. Binary logistic stepwise regression analysis showed that only gender significantly correlated with hypoglycemia (B = 1.17, p = 0.017). Importantly, male patients had a significantly higher incidence of hypoglycemia than female patients (male = 20/52, female = 9/50, p = 0.022), although male patients required significantly lower insulin doses to maintain glycemic control than female patient (p = 0.00).Conclusion: Male patients with longstanding T2D had a higher incidence of hypoglycemia than female patients during intensive insulin therapy.Trial registration: ClinicalTrials.gov identifier, ChiCTR-IPR-15007340.
- Subjects
HYPOGLYCEMIA; INSULIN therapy; TYPE 2 diabetes; MALES; PATIENT self-monitoring
- Publication
Diabetes Therapy, 2018, Vol 9, Issue 5, p1969
- ISSN
1869-6953
- Publication type
Article
- DOI
10.1007/s13300-018-0492-3