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- Title
Fine‐Tuning the Relevance of Molecular Targets to Pediatric Cancer: Addressing Additional Layers of Complexity.
- Authors
Charlab, Rosane; Burckart, Gilbert J.; Reaman, Gregory H.
- Abstract
The Research to Accelerate Cures and Equity (RACE) for Children Act requires an assessment of molecular targets relevant to pediatric cancer. Due to the biological complexity, candidate molecular targets have been primarily evaluated based on single features such as the presence of mutations or deregulated expression. As the understanding of tumor biology evolves, the relevance of certain molecular targets may need to be assessed at isoform and/or mutation variant level to optimize tailored therapeutic interventions.
- Subjects
DRUG target; CHILDHOOD cancer; ACT Assessment; RACE; BIOLOGY
- Publication
Clinical Pharmacology & Therapeutics, 2023, Vol 113, Issue 5, p957
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1002/cpt.2759