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- Title
The Metabolic and Endocrine Effects of a 12-Week Allulose-Rich Diet.
- Authors
Cayabyab, Kevin B.; Shin, Marley J.; Heimuli, Micah S.; Kim, Iris J.; D'Agostino, Dominic P.; Johnson, Richard J.; Koutnik, Andrew P.; Bellissimo, Nick; Diamond, David M.; Norwitz, Nicholas G.; Arroyo, Juan A.; Reynolds, Paul R.; Bikman, Benjamin T.
- Abstract
The global rise in type 2 diabetes (T2D) and obesity necessitates innovative dietary interventions. This study investigates the effects of allulose, a rare sugar shown to reduce blood glucose, in a rat model of diet-induced obesity and T2D. Over 12 weeks, we hypothesized that allulose supplementation would improve body weight, insulin sensitivity, and glycemic control. Our results showed that allulose mitigated the adverse effects of high-fat, high-sugar diets, including reduced body weight gain and improved insulin resistance. The allulose group exhibited lower food consumption and increased levels of glucagon-like peptide-1 (GLP-1), enhancing glucose regulation and appetite control. Additionally, allulose prevented liver triglyceride accumulation and promoted mitochondrial uncoupling in adipose tissue. These findings suggest that allulose supplementation can improve metabolic health markers, making it a promising dietary component for managing obesity and T2D. Further research is needed to explore the long-term benefits and mechanisms of allulose in metabolic disease prevention and management. This study supports the potential of allulose as a safe and effective intervention for improving metabolic health in the context of dietary excess.
- Subjects
BIOLOGICAL models; INSULIN sensitivity; FOOD consumption; PATIENT safety; ADIPOSE tissues; RESEARCH funding; BODY weight; GLYCEMIC control; GLUCAGON-like peptide 1; BLOOD sugar; RATS; INSULIN resistance; FRUCTOSE; TYPE 2 diabetes; ANIMAL experimentation; WESTERN diet; TRIGLYCERIDES; LIVER; OBESITY; WEIGHT gain
- Publication
Nutrients, 2024, Vol 16, Issue 12, p1821
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16121821