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- Title
Walnut (Juglans regia L.) Oligopeptides Alleviate Alcohol-Induced Acute Liver Injury through the Inhibition of Inflammation and Oxidative Stress in Rats.
- Authors
Liu, Rui; Hao, Yun-Tao; Zhu, Na; Liu, Xin-Ran; Mao, Rui-Xue; Kang, Jia-Wei; Hou, Chao; Zhang, Ting; Li, Yong
- Abstract
The study was aimed at investigating the effects of walnut oligopeptides (WOPs) on alcohol-induced acute liver injury and its underlying mechanisms. Male Sprague Dawley (SD) rats were randomly assigned to six groups: normal control, alcohol control, whey protein (440 mg/kg.bw), and three WOPs (220 mg/kg.bw, 440 mg/kg.bw, 880 mg/kg.bw) groups. After 30 days of gavage, ethanol with a volume fraction of 50%, administered at a dose of 7 g/kg.bw., caused acute liver injury. A righting reflex experiment and a blood ethanol concentration evaluation were then performed. Serum biochemical parameters, inflammatory cytokines, liver alcohol metabolism enzymes, oxidative stress biomarkers, liver nuclear factor-κB (NF-κB p65), and cytochrome P4502E1 expression were determined. The results revealed that the intervention of 440 mg/kg and 880 mg/kg WOPs could alleviate the degree of intoxication, decrease blood ethanol concentration, alleviate alcohol-induced hepatic steatosis, enhance the activity of hepatic ethanol metabolizing enzymes and antioxidant capacity, reduce lipid oxidation products and pro-inflammatory factor contents, and inhibit the expression of NF-κBp65 in the livers of rats. The outcomes of the study suggest that WOPs have beneficial effects on liver damage caused by acute ethanol binge drinking, with the high-dose WOPs (880 mg/kg.bw) exerting the most pronounced hepatoprotective effect.
- Subjects
BLOOD serum analysis; INFLAMMATION prevention; BIOCHEMISTRY; CYTOKINES; CYTOCHROME P-450; WALNUT; OLIGOPEPTIDES; ALCOHOLIC liver diseases; ANIMAL experimentation; REFLEXES; NF-kappa B; OXIDATIVE stress; RATS; GENE expression; TREATMENT effectiveness; PLANT extracts; ETHANOL; INFLAMMATORY mediators; ACUTE diseases; LIVER failure
- Publication
Nutrients, 2023, Vol 15, Issue 9, p2210
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15092210