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- Title
24,25-Dihydroxy Vitamin D and Vitamin D Metabolite Ratio as Biomarkers of Vitamin D in Chronic Kidney Disease.
- Authors
Lee, Seunghye; Chung, Hye Jin; Jung, Sehyun; Jang, Ha Nee; Chang, Se-Ho; Kim, Hyun-Jung; Cho, Min-Chul
- Abstract
The appropriate management of vitamin D deficiency and hyperparathyroidism is essential to prevent metabolic bone disorder (MBD) and cardiovascular diseases in chronic kidney disease (CKD). Recently, the 24,25-dihydroxyvitamin D [24,25(OH)2D] and vitamin D metabolite ratio (VMR), i.e., the ratio of 24,25(OH)2D to 25-hydroxyvitamin D [25(OH)D], have emerged as biomarkers of vitamin D level. We analyzed the usefulness of vitamin D biomarkers for the evaluation of MBD in patients with CKD. We analyzed blood and urine samples from 208 outpatients with CKD stage G2–G5. 25(OH)D showed a poor correlation with the estimated glomerular filtration rate (eGFR). Conversely, the 24,25(OH)2D level and VMR were significantly correlated with eGFR and the intact parathyroid hormone level. In conclusion, 24,25(OH)2D and VMR have the potential to be vitamin D biomarkers for the detection of MBD in CKD patients.
- Subjects
HYPERPARATHYROIDISM treatment; VITAMIN D metabolism; BIOMARKERS; CARDIOVASCULAR diseases risk factors; GLOMERULAR filtration rate; CHRONIC diseases; OSTEOPENIA; HEALTH outcome assessment; KIDNEY diseases; TUMOR classification; PARATHYROID hormone; VITAMIN D deficiency; DISEASE risk factors; DISEASE complications
- Publication
Nutrients, 2023, Vol 15, Issue 3, p578
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15030578