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- Title
Prevalence of Sarcopenia and Its Impact on Cardiovascular Events and Mortality among Dialysis Patients: A Systematic Review and Meta-Analysis.
- Authors
Wathanavasin, Wannasit; Banjongjit, Athiphat; Avihingsanon, Yingyos; Praditpornsilpa, Kearkiat; Tungsanga, Kriang; Eiam-Ong, Somchai; Susantitaphong, Paweena
- Abstract
Sarcopenia in end-stage kidney disease patients requiring dialysis is a frequent complication but remains an under-recognized problem. This meta-analysis was conducted to determine the prevalence of sarcopenia and explored its impacts on clinical outcomes, especially cardiovascular events, and mortality in dialysis patients. The eligible studies were searched from PubMed, Scopus, and Cochrane Central Register of Controlled trials up to 31 March 2022. We included studies that reported the interested outcomes, and the random-effects model was used for analysis. Forty-one studies with 7576 patients were included. The pooled prevalence of sarcopenia in dialysis patients was 25.6% (95% CI 22.1 to 29.4%). Sarcopenia was significantly associated with higher mortality risk (adjusted OR 1.83 (95% CI 1.40 to 2.39)) and cardiovascular events (adjusted OR 3.80 (95% CI 1.79 to 8.09)). Additionally, both low muscle mass and low muscle strength were independently related to increased mortality risk in dialysis patients (OR 1.71; 95% CI (1.20 to 2.44), OR 2.15 (95% CI 1.51 to 3.07)), respectively. This meta-analysis revealed that sarcopenia was highly prevalent among dialysis patients and shown to be an important predictor of cardiovascular events and mortality. Future intervention research to alleviate this disease burden in dialysis patients is needed.
- Subjects
TREATMENT of chronic kidney failure; MORTALITY risk factors; CHRONIC kidney failure complications; CARDIOVASCULAR diseases risk factors; CHRONIC kidney failure; ONLINE information services; META-analysis; CONFIDENCE intervals; SYSTEMATIC reviews; SARCOPENIA; RISK assessment; HEMODIALYSIS patients; DISEASE prevalence; PSYCHOSOCIAL factors; DESCRIPTIVE statistics; MUSCLE strength; HEMODIALYSIS; ODDS ratio; MEDLINE
- Publication
Nutrients, 2022, Vol 14, Issue 19, p4077
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14194077