We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mediation Effect of Platelet Traits on Associations of Central Obesity with Aging Biomarkers in Rural Adults of Henan, China.
- Authors
Chen, Xinwei; Li, Ruiying; Hou, Xiaoyu; Wang, Yuqin; Pan, Mingming; Kang, Ning; Yuchi, Yinghao; Liao, Wei; Liu, Xiaotian; Mao, Zhenxing; Huo, Wenqian; Wang, Chongjian; Hou, Jian
- Abstract
Background: To assess the associations of platelet traits and obesity indices with aging biomarkers (telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN)). Methods: A cross-sectional study was performed among 5091 rural Chinese adults. Obesity indices (waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR)) and platelet traits (plateletcrit (PCT), platelet large cell ratio (P-LCR), mean platelet volume (MPV) and platelet distribution width (PDW)) were collected by physical examination. The aging biomarkers were determined by quantitative real-time polymerase chain reaction. Generalized linear regression models and mediation analysis were applied to explore the relationships between platelet traits, obesity indices, and aging biomarkers. Results: The mean age of the participants was 56 years (range: 18–79). Each one-unit increment in WC, WHR and WHtR were related to a 0.316 (95% confidence interval (CI): −0.437, −0.196), 0.323 (95% CI: −0.513, −0.134) and 0.277 (95% CI: −0.400, −0.153) decrease in relative TL; or a 0.102 (95% CI: −0.197, −0.007), 0.109 (95% CI: −0.258, −0.041) and 0.101 (95% CI: −0.199, −0.004) decrease in relative mtDNA-CN. The proportions of obesity indices with aging biomarkers mediated by platelet indices ranged from 2.85% to 10.10%. Conclusions: Increased central obesity indices in relation to shortened relative TL or decreased mtDNA-CN were mediated by platelet traits, indicating that obesity in association with the accelerated aging process may be partially attributable to abnormal platelet activity.
- Subjects
CHINA; OBESITY; BIOMARKERS; TELOMERES; STATURE; DNA; GENETICS; CONFIDENCE intervals; RURAL conditions; BLOOD platelets; CROSS-sectional method; BLOOD platelet activation; MITOCHONDRIA; WAIST-hip ratio; AGING; FACTOR analysis; WAIST circumference; DESCRIPTIVE statistics; DATA analysis software; MEAN platelet volume
- Publication
Nutrients, 2022, Vol 14, Issue 17, p3597
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14173597