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- Title
Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis.
- Authors
Yang, Shang-Yu; Fang, Chi-Jung; Chen, Yu-Wen; Chen, Wan-Ping; Lee, Li-Ya; Chen, Chin-Chu; Lin, Yen-You; Liu, Shan-Chi; Tsai, Chun-Hao; Huang, Wei-Chien; Wu, Yang-Chang; Tang, Chih-Hsin
- Abstract
Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability. Hericium erinaceus is a large edible mushroom with several known medicinal functions. However, the therapeutic effects of H. erinaceus in OA are unknown. In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that H. erinaceus mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain. ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with H. erinaceus mycelium. In addition, H. erinaceus mycelium reduced the synthesis of proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in OA cartilage and synovium. H. erinaceus mycelium shows promise as a functional food in the treatment of OA.
- Subjects
KNEE osteoarthritis; DISEASE progression; BIOLOGICAL models; CYTOKINES; INTERLEUKINS; FUNCTIONAL foods; IN vivo studies; EDIBLE mushrooms; ANIMAL experimentation; BONE resorption; TREATMENT effectiveness; RATS; TUMOR necrosis factors; ARTICULAR cartilage
- Publication
Nutrients, 2022, Vol 14, Issue 13, p2605
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14132605