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- Title
The Effectiveness and Safety of Multi-Strain Probiotic Preparation in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Controlled Study.
- Authors
Skrzydło-Radomańska, Barbara; Prozorow-Król, Beata; Cichoż-Lach, Halina; Majsiak, Emilia; Bierła, Joanna Beata; Kanarek, Ewelina; Sowińska, Agnieszka; Cukrowska, Bożena; Grangette, Corinne
- Abstract
The aim of this randomized double-blind placebo-controlled study was to evaluate the effectiveness and safety of multi-strain probiotic in adults with diarrhea-predominant irritable bowel syndrome (IBS-D). The patients were randomized to receive a mixture of Lactobacillus, Bifidobacterium, and Streptococcus thermophilus strains or placebo for eight weeks. Primary endpoints included changes in symptom severity and improvement assessed with the IBS Severity Scoring System (IBS-SSS) and Global Improvement Scale (IBS-GIS). The probiotic in comparison with placebo significantly improved the IBS symptom severity (the change of total IBS-SSS score from baseline −165.8 ± 78.9 in the probiotic group and −105.6 ± 60.2 in the placebo group, p = 0.005) and in the specific scores related to the severity of pain (p = 0.015) and the quality of life (p = 0.016) after eight weeks of intervention. The probiotic group indicated an improvement in symptoms with the use of the IBS-GIS compared with the placebo group after four (p = 0.04) and eight weeks (p = 0.003). The occurrence of adverse events did not differ between study groups. In conclusion, the multi-strain probiotic intervention resulted in a significant improvement in IBS symptoms evaluated with the use of both IBS-SSS and IBS-GIS scales. The results suggest that the studied probiotic preparation is well tolerated and safe and can offer benefits for patients with IBS-D. (registration number in Clinicaltrials.gov NCT 04662957).
- Subjects
IRRITABLE colon treatment; BIFIDOBACTERIUM; DIARRHEA; PROBIOTICS; TREATMENT effectiveness; RANDOMIZED controlled trials; STREPTOCOCCUS; SEVERITY of illness index; QUALITY of life; BLIND experiment; STATISTICAL sampling; LACTOBACILLUS
- Publication
Nutrients, 2021, Vol 13, Issue 3, p756
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13030756