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- Title
Stronger antioxidant enzyme immunoreactivity of Populus tomentiglandulosa extract than ascorbic acid in rat liver and kidney.
- Authors
Choong-Hyun Lee; Joon Ha Park; Ji Hyeon Ahn; Jong Dai Kim; Jun Hwi Cho; Tae-Kyeong Lee; Moo-Ho Won
- Abstract
Objective(s): Populus species have various pharmacological properties, including antioxidant activity. In this study, the effects of Populus tomentiglandulosa extract (PTE) on histopathology and antioxidant enzymes in the rat liver and kidney were examined. Materials and Methods: Sprague-Dawley rats were assigned to three groups; (1) normal diet fed group, (2) ascorbic acid-containing diet-fed group as a positive control, (3) PTE-containing diet-fed group. The histopathology in the rat liver and kidney was examined by hematoxylin and eosin staining. The effect of PTE was examined in the rat liver and kidney by immunohistochemistry for antioxidant enzymes, such as superoxide dismutases (SOD1 and SOD2), catalase (CAT), and glutathione peroxidase (GPx). Results: No marked histopathological alterations were observed in the liver and kidney of the PTE-containing diet-fed group. In the liver, the mean numbers of SOD1, SOD2, CAT, and GPx immunoreactive cells were significantly increased in the PTE-containing diet-fed rats, compared with those in the normal- and ascorbic acid-containing diet-fed rats. In the kidney, all SOD1, SOD2, CAT, and GPx immunoreactive structures were significantly increased in the PTE-containing diet-fed group, compared with those in the normal- and ascorbic acid-containing diet-fed groups. Conclusion: Results showed that PTE treatment significantly increased antioxidant enzymes in the rat liver and kidney, and we suggest that PTE might have hepato- and nephro-protective potentials against oxidative stress.
- Subjects
VITAMIN C; KIDNEYS; POPLARS; LIVER; GLUTATHIONE peroxidase
- Publication
Iranian Journal of Basic Medical Sciences, 2019, Vol 22, Issue 8, p963
- ISSN
2008-3866
- Publication type
Article
- DOI
10.22038/ijbms.2019.34926.8296