We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Primary myxedema with thyrotrophin-binding inhibitor immunoglobulins. Clinical and laboratory findings in 15 patients.
- Authors
Konishi, Junji; Iida, Yasuhiro; Kasagi, Kanji; Misaki, Takashi; Nakashima, Tetsuo; Endo, Keigo; Mori, Toru; Shinpo, Shinichiro; Nohara, Yachiyo; Matsuura, Nobuo; Torizuka, Kanji; Konishi, J; Iida, Y; Kasagi, K; Misaki, T; Nakashima, T; Endo, K; Mori, T; Shinpo, S; Nohara, Y
- Abstract
In a screening of 43 patients with primary myxedema, 9 patients were found to have IgG that inhibits the binding of 125I-thyrotrophin to its receptor (thyrotrophin-binding inhibitor immunoglobulins). Preparations of IgG from these patients did not stimulate thyroidal cyclic adenosine monophosphate generation and blocked thyroid stimulation by thyrotrophin in vitro. Clinical and laboratory features of 15 patients with this inhibitor, including 6 who were previously known, were compared with those of patients without the inhibitor. The patients with inhibitor, 2 men and 13 women, had onset of their hypothyroidism from age 2 to 49 years, and thyroid uptake in these patients was significantly lower than that in patients without inhibitor. Transient hypothyroidism was seen in all 5 infants born to 4 mothers having potent inhibitor immunoglobulins. These clinical findings indicate that thyrotrophin-receptor-blocking antibodies play a pathogenic role in a group of patients with primary myxedema.
- Subjects
THYROTROPIN; IMMUNOGLOBULINS; MYXEDEMA; HYPOTHYROIDISM
- Publication
Annals of Internal Medicine, 1985, Vol 103, Issue 1, p26
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-103-1-26