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- Title
Surgery on a dilated aorta associated with a connective tissue disease or inflammatory vasculitis in children and adolescents.
- Authors
Kwak, Jae Gun; Kim, Woong-Han; Kim, Eung Re; Kang, Yoon Jin; Min, Jooncheol; Lim, Jae Hong; Kim, Yong Jin
- Abstract
<bold>Introduction: </bold>This research investigated patients who underwent surgery for a dilated aorta associated with a connective tissue disease or inflammatory vasculitis in children and adolescents.<bold>Materials and Methods: </bold>The medical records of 11 patients who underwent aortic surgery for dilatation resulting from a connective tissue disease or inflammatory vasculitis between 2000 and 2017 were retrospectively reviewed.<bold>Results: </bold>The median age and body weight of the patients were 9.6 years (range 5.4 months-15.5 years) and 25.8 kg (range 6.8-81.5), respectively. The associated diseases were Marfan syndrome (n = 3), Loeys-Dietz syndrome (n = 3), Kawasaki disease (n = 1), Takayasu arteritis (n = 1), PHACE syndrome (n = 1), tuberous sclerosis (n = 1), and unknown (n = 1). The most common initially affected area was the ascending aorta. During the 66.4 ± 35.9 months of follow-up, two Marfan syndrome patients died, and four patients (one Marfan syndrome and three Loeys-Dietz syndrome) had repeated aortic operation. Except for one patient, the functional class was well maintained in all patients who were followed up.<bold>Conclusion: </bold>Cases of surgical treatment for a dilated aorta associated with a connective tissue disease and inflammatory vasculitis are rare in children and adolescents at our institution. Most of the patients in this study showed a tolerable postoperative course. However, the aorta showed progressive dilation over time even after surgical treatment, especially in patients with Loeys-Dietz syndrome. In these patients, close and more frequent regular follow-up is required.
- Subjects
CONNECTIVE tissue diseases; ADOLESCENCE; MUCOCUTANEOUS lymph node syndrome; AORTA surgery; VASCULITIS; MARFAN syndrome
- Publication
Cardiology in the Young, 2019, Vol 29, Issue 5, p564
- ISSN
1047-9511
- Publication type
journal article
- DOI
10.1017/S1047951118002299