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- Title
Active matrix metalloproteinase-8 and periodontal bacteria depending on periodontal status in patients with rheumatoid arthritis.
- Authors
Kirchner, A.; Jäger, J.; Krohn‐Grimberghe, B.; Patschan, S.; Kottmann, T.; Schmalz, G.; Mausberg, R. F.; Haak, R.; Ziebolz, D.
- Abstract
Background and Objectives The aim of this clinical cross-sectional study was to determine the level of active matrix metalloproteinase-8 (a MMP-8) and periodontal pathogenic bacteria in gingival crevicular fluid in patients with rheumatoid arthritis ( RA) with varying periodontal conditions. Material and Methods In total, 103 patients with RA and 104 healthy controls ( HC) were included. The assessment of periodontal status included periodontal probing depth, bleeding on probing and clinical attachment loss. Periodontal disease was classified as healthy/mild, moderate or severe. For the determination of a MMP-8 levels using enzyme-linked immunosorbent assay and periodontal pathogenic bacteria using polymerase chain reaction, samples of gingival crevicular fluid were taken from the deepest gingival pockets. The statistical analyses used included a Mann-Whitney U-test, a chi-squared test or a Fisher's exact test, and the significance level was set at α = 5%. Results We found that 65% of patients with RA and 79% of HC had moderate to severe periodontal disease ( p = 0.02). The prevalence of periodontal pathogens was almost equal ( p > 0.05). Furthermore, depending on periodontal disease severity only minor differences in bacterial prevalence were detected. With increasing severity of periodontal disease, higher a MMP-8 levels were observed. Accordingly, a significant difference in patients with moderate periodontal disease ( RA: 15.3 ± 13.8; HC: 9.1 ± 9.1; p ≤ 0.01) and severe periodontal disease ( RA: 21.7 ± 13.3; HC: 13.1 ± 8.6; p = 0.07) was detected, with a greater tendency in the latter group. Conclusion The increased a MMP-8 levels in the RA group indicate that the presence of RA appears to have an influence on the host response at a comparable level of bacterial load and periodontal disease severity.
- Subjects
PERIODONTAL disease; RHEUMATOID arthritis; MATRIX metalloproteinases; GINGIVAL fluid; CLINICAL attachment loss (Periodontal disease); PATIENTS; CHI-squared test; ENZYME-linked immunosorbent assay; EXUDATES &; transudates; FISHER exact test; GINGIVA; POLYMERASE chain reaction; PROBABILITY theory; MANN Whitney U Test
- Publication
Journal of Periodontal Research, 2017, Vol 52, Issue 4, p745
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/jre.12443