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- Title
Thermal stability evaluation of doping compounds before GC-MS analysis by DSC.
- Authors
Hadef, Y.; Kaloustian, J.; Nicolay, A.; Portugal, H.
- Abstract
The Medical Commission of the International Olympic Committee forbids the use of anabolic androgenic steroids, β-agonists, stimulant and narcotic compounds to improve athletic performance. In this work, we evaluated the thermal stability of 17 compounds by the use of the DSC for their potential GC-MS analysis either under free form or under TMS derivative form. In DSC, esterified and unesterified anabolic steroids were characterized by a true melting peak, followed by a large exothermic peak at about 251–316°C due to oxidative degradation. They could be analysed by GC-MS mainly under TMS derivatives. Hydroxylated and unhydroxylated stimulant compounds (xanthines) seemed to be more stable at high temperature. As unhydroxylated xanthines were not silylated with BSTFA - TMCS, their GC analysis would be done under their free forms. TMS derivatisation of albuterol hemisulfate and codeine phosphate is preferable. In our conditions, to analyse by GC-MS all 17 doping compounds in the same GC-MS run, the optimal silylation temperature and best column initial temperature were determined at both 60°C.
- Subjects
DOPING in sports; STIMULANTS; ANABOLIC steroids; XANTHINE; ALBUTEROL; ADRENERGIC beta agonists; CODEINE derivatives; THERMAL analysis
- Publication
Journal of Thermal Analysis & Calorimetry, 2008, Vol 93, Issue 2, p553
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-006-8300-0