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- Title
Effects of Physical Exercise on Cardiometabolic Biomarkers and Inflammatory Markers in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Authors
Hejazi, Keyvan; Ferrari, Filipe
- Abstract
Background: The prevalence of obesity among children as well as the beneficial effects of physical exercise (PE) on weight loss has been determined by modulating the secretory factors of adipose tissue. PE has also been shown to have beneficial effects on obesity. Objective: The objective of this systematic review and meta-analysis was to investigate the effects of physical exercise (PE) on adiponectin and other important health markers in children. Data sources: We searched 6 electronic databases (PubMed/Medline, Embase, Cochrane Library, Cinahl, Scopus, and Web of Science) and Google Scholar for randomized controlled trials from inception to December 15, 2021. We used random-effects models to estimate weighted mean difference (WMD) with 95% confidence intervals (CI). Study selection: Fourteen studies were included (N = 468 participants; mean age: 14 years). Results: In general, PE increased adiponectin (WMD: 0.91 µg/mL; 95% CI, 0.27 to 1.55, p = 0.005), high-density lipoprotein cholesterol (HDL-C) (WMD: 1.01 mg/dL; 95% CI, 0.33 to 1.69, p = 0.004), and VO2max (WMD: 2.52 mL.kg.min; 95% CI, 1.41 to 3.62, p = 0.00,001). The levels of c-reactive protein (WMD: -0.37 mg/L; 95% CI, -0.57 to -0.17, p = 0.0003), insulin (WMD: -4.61 μIU/ml; 95% CI, -5.46 to -3.76, p = 0.00,001), fasting glucose (WMD: -5.11 mg/dL; 95% CI, -7.88 to -2.34, p = 0.0003), and insulin resistance index (WMD: -1.44; 95% CI, -1.92 to -0.96, p = 0.00,001), decreased significantly. Conclusion: Our study showed that PE may increase the level of adiponectin, HDL-C, and VO2max in children.
- Subjects
INFLAMMATION prevention; CARDIOVASCULAR diseases risk factors; BIOMARKERS; ONLINE information services; MEDICAL databases; CINAHL database; HDL cholesterol; C-reactive protein; META-analysis; MEDICAL information storage &; retrieval systems; CONFIDENCE intervals; CHILDHOOD obesity; SYSTEMATIC reviews; EXERCISE physiology; BLOOD sugar; LDL cholesterol; INSULIN; ADIPONECTIN; DESCRIPTIVE statistics; MEDLINE; DATA analysis software; REACTIVE oxygen species; INSULIN resistance; OXYGEN in the body; CHILDREN
- Publication
Biological Research for Nursing, 2022, Vol 24, Issue 4, p519
- ISSN
1099-8004
- Publication type
Article
- DOI
10.1177/10998004221099573