We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: A brief discussion of concepts.
- Authors
Ashauer, Roman; Agatz, Annika; Albert, Carlo; Ducrot, Virginie; Galic, Nika; Hendriks, Jan; Jager, Tjalling; Kretschmann, Andreas; O'Connor, Isabel; Rubach, Mascha Nadine; Nyman, Anna-Maija; Schmitt, Walter; Stadnicka, Julita; van den Brink, Paul J.; Preuss, Thomas G.
- Abstract
We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined. Environ. Toxicol. Chem. 2011;30:2519-2524. © 2011 SETAC
- Subjects
TOXICOLOGY; SIMULATION methods &; models; BIOENERGETICS; DOSE-response relationship in biochemistry; BIOCHEMICAL research
- Publication
Environmental Toxicology & Chemistry, 2011, Vol 30, Issue 11, p2519
- ISSN
0730-7268
- Publication type
Article
- DOI
10.1002/etc.639