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- Title
Quantitative structure--activity relationships for weak acid respiratory uncouplers to Vibrio fisheri
- Authors
Schultz, T. W.; Cronin, M. T. D.
- Abstract
Acute toxicity values (5- and 30-min Vibrio fisheri 50% luminescenceinhibition) of 16 organic compounds thought to elicit their responsevia the weak acid respiratory uncoupling mechanism of toxic action were secured from the literature. Regression analysis of toxicities revealed that a measured 5-min V. fisheri potency value can be used as a surrogate for the 30-min value. Regression analysis of toxicity (30-min for potency [log pT{sub}30{end}{sup}-1{end}]) versus hydrophobicity, measured as the 1-octanol/water partition coefficient (log K{sub}OW{end}), was used to formulate a quantitative structure-activity relationship (QSAR). The equation log pT{sub}30{end}{sup}-1{end} = 0.489(log K{sub}OW{end}) + 0. 126 was found to be a highly predictive model (r{sup}2{end} adj. = 0.848). This V. fisheri QSAR is statisticallysimilar to QSARs generated from weak acid uncoupler potency data forPimephales promelas survivability and Tetrahymena pyriformis population growth impairment. This work, therefore, suggests that the weak acid respiratory uncoupling mechanism of toxic action is present in V.fisheri, and as such is not restricted to mitochondria-containing organisms.
- Subjects
BIOLOGICAL monitoring; FISHES
- Publication
Environmental Toxicology & Chemistry, 1997, Vol 16, Issue 2, p357
- ISSN
0730-7268
- Publication type
Article
- DOI
10.1897/1551-5028(1997)016<0357:QSARFW>2.3.CO;2