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- Title
Adenosine Triphosphate Metabolism Measured by Phosphorus Magnetic Resonance Spectroscopy: A Potential Biomarker for Multiple Sclerosis Severity.
- Authors
Kauv, Paul; ayache, Samar S.; Créange, alain; Chalah, Moussa a.; Lefaucheur, Jean-Pascal; Hodel, Jérôme; Brugières, Pierre
- Abstract
Background/Aims: Phosphorus magnetic resonance spectroscopy (31 P-MRS) has previously shown abnormal changes in energy metabolites in the brain of multiple sclerosis (MS) patients. However, the relationship between these energy metabolites - particularly adenosine triphosphate (ATP) - and the disease severity remains unclear. The objective of this study was to determine whether measuring ATP metabolites can help to predict disease severity in MS patients. Methods: 31 P-MRS at 3 tesla was performed in 9 relapsing remitting (RRMS), 9 secondary progressive MS patients (SPMS), and 10 age-matched healthy controls. ATP metabolites (expressed as %) in normally appearing white matter of the centrum semiovale were compared between patients and healthy controls. The relationship between Expanded Disability Status Scale (EDSS) and ATP metabolites was evaluated. Results: RRMS and SPMS patients had higher phosphocreatine (PCr) and lower phosphodiesters than healthy controls. In addition, RRMS patients had higher ß-ATP% than SPMS patients. ß-ATP% was negatively correlated with EDSS in all patients. Conclusion: Our findings suggest a defective PCr metabolism in both patient groups, and a higher state of energy production in RRMS that might reflect a compensatory mechanism in face of the increased needs. The correlation of ß-ATP with EDSS makes it a candidate biomarker for assessing MS disease severity.
- Subjects
MULTIPLE sclerosis; ADENOSINE triphosphate metabolism; BIOMARKERS; NUCLEAR magnetic resonance spectroscopy; ENERGY metabolism regulation; PHOSPHODIESTERS; PHOSPHOCREATINE; SEVERITY of illness index; PATIENTS
- Publication
European Neurology, 2017, Vol 77, Issue 5/6, p316
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000475496