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- Title
Efficient One-Pot Cross-Coupling of Two Aryl Halides by Stannylation/Stille Reaction in Water under Microwave Irradiation.
- Authors
Tan, Xin; Zhou, Zi Jie; Zhang, Jia Xin; Duan, Xin Hong
- Abstract
A simple and highly efficient one-pot approach has been developed for the Pd(PPh3)4-catalyzed cross-coupling of two different aryl or heteroaryl bromides/iodides. This method involves the combined use of microwave irradiation and water as a single solvent to achieve sequential stannylation and Stille cross-coupling reactions, which allows rapid access to a wide variety of biaryls in good to high yields. Furthermore, utilizing this step-economical protocol, 2,5-dibromopyridine was iteratively diarylated and the Boscalid intermediate was also synthesized in a one-pot manner.
- Subjects
CHEMICAL synthesis; WATER chemistry; MICROWAVE chemistry; PALLADIUM; TIN research
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 24, p5153
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402404