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- Title
THE SEVERITY OF GINGIVAL ENLARGEMENT INDUCED BY CYCLOSPORIN-A AND NIFIDIPINE AN EXPERIMENTAL STUDY IN RABBIT.
- Authors
AL-Bayaty, F. H.; AL-Tay, Basma O.; AL-Kushali, Salah S.; Mahmmod, Likaa
- Abstract
Objectives: The present study was undertaken to estimate the severity of gingival enlargement induced by Cyclosporin – A and Nifedipine separately and in combination. Material & Methods: Thirty adult rabbits were used in this study. , divided equally into 3 main experimental groups. The first group received 10mg/kg/day Nifedipine, The second received 10mg/kg/day CsA, the third received combination of 10mg/kg/day Nifedipine and CsA by gastric feeding from day 1 till day 70. Alginate impressions were taken for the anterior segments of the maxilla and mandible for each animal on the days 0, 30, 70, and 110. Gingival enlargement was assessed on stone study models according to Seymour’s method. Results: revealed a highly significant difference in the mean values of the gingival enlargement scores in the experimental group that received combination of CsA and Nifedipine, compared to that received either CsA or Nifedipine,and in the group that receive CsA compared to that received Nifedipine on day 70 of the experiment. Conclusion: the effect of CsA in causing gingival enlargement was significantly more than the effect of Nifedipne, While the effect of the combination of the two drugs caused significantly more gingival enlargement than the effect of one of the drugs alone, Drug withdrawal shows partial regression of gingival enlargement on day 110 in the experimental groups.
- Publication
Malaysian Dental Journal, 2008, Vol 29, Issue 2, p160
- ISSN
0126-8023
- Publication type
Article